U.N.C.L.E. is an acronym for the fictional United Network Command for Law and Enforcement, a secret international intelligence agency featured in the 1960s American television series The Man from U.N.C.L.E. and The Girl from U.N.C.L.E..

U.N.C.L.E. is an organization consisting of agents of all nationalities. Responsible for "maintaining political and legal order anywhere in the world", it is multinational in makeup and international in scope, protecting and defending nations regardless of size or political persuasion. U.N.C.L.E. operates in Communist and Third World countries the same way that it does in the Western nations. In the episode entitled "The Shark Affair," (episode 4 from season 1, from 1964) enforcement agent of U.N.C.L.E. Napoleon Solo reveals that U.N.C.L.E. is sponsored by the US, the Soviet Union, the United Kingdom, the Netherlands, Greece, Spain, Italy and Yugoslavia. Its primary opponent is the independent international criminal organization, THRUSH (Technological Hierarchy for the Removal of Undesirables and the Subjugation of Humanity).